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Mass Spectrometry Facility

Mass spectrometry is routinely used to confirm the molecular weight and elemental composition of synthesized compounds, to investigate the structure of unknowns, and to analyze the concentration of species present in complex mixtures. Requests for mass spectral analysis can be made by submitting either of the following forms to the Instrument Center.

Sample Analysis Submission Form

Available Instrumentation

  • ThermoFinnigan MAT95XL high resolution magnetic sector mass spectrometer with GC and LC/MS capabilities (Funded by NSF CHE-0091977)
  • LCQ Advantage IonTrap LC/MS and surveyor HPLC system (Funded by NSF CHE-0091977)
  • Thermo X-Series 2 ICP-MS (Funded by NSF CHE-0959565)
  • Bruker Daltonics SolariX 12 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
  • Hewlett Packard 5890 Series II gas chromatograph with 5972 mass selective detector and HP 7673 auto sampler

Nominal and accurate mass determinations are available for the following ionization modes:

  • Electron Import (EI)
  • Desorption Electron Impact (DEI)
  • Chemical Ionization (CI)
  • Desorption Chemical Ionization (DCI)
  • Fast Atom Bombardment (FAB)

Structural Analysis Techniques Available

  • Molecular weight determination
  • Elemental composition using high resolution tuning and accurate mass measurement
  • GC/MS and LC/MS for analysis of components in complex mixtures
  • MS/MS, MSn, linked scanning for daughter, parent and neutral loss used for investigating composition of selected ions, determination of fragmentation pathways and study of gas phase reactions.
  • Library searching for identification of unknowns:
  • Wiley Library 138,000 spectra
  • NIST 62,000+ spectra

Quantitative Analysis

  • Selected ion recording (SIR) and selected reaction monitoring (SRM) for enhanced sensitivity

Ability to combine techniques for enhanced specificity:

  • High resolution GC/MS or LC/MS
  • MS/MS with GC/MS or LC/MS