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CHE 523: Bioinorganic Chemistry

This course covers current topics in bioinorganic chemistry and medicinal inorganic chemistry. The course begins with a review of the distribution and abundance of metal ions in biological systems and their environment and the basics of coordination chemistry.   Transport of metal ions into and within cells is covered and diseases associated with errors in metal ion trafficking are discussed. This topic leads into mechanistic and spectroscopic studies of several selected metalloenzymes.   Topics covered in nucleic acids include the role of metal ions in catalytic RNAs and the mechanism of action of anticancer metallodrugs such as platinum drugs and bleomycin.   Finally, metal ion complexes used as radiopharmaceuticals and in magnetic resonance imaging are covered.