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CHE 530: Analytical Mass Spectrometry

This course covers modern analytical mass spectrometry techniques and their application to solving research problems.  Part of the course typically focuses on instrumentation – mass analyzers, ionization sources, detectors, inlet systems, etc.  The analytical advantages of each method will be explored, as will an understanding of the fundamental principles which underlie each methodology.  In addition, the course examines sophisticated experimental methods, such as tandem mass spectrometry (MS/MSO) for structural elucidation, on-line separations, mass spectrometry (GC/MS, LC/MS, CE/MS, etc.) in which the mass spectrometer serves as a detector for separations techniques, and quantification.  Another portion of the course is typically dedicated to mass spectral interpretation.  Topics such as isotope distribution and fragmentation patterns (for organic compounds as well as biological compounds) as useful tools in mass spectral interpretation are covered.  Throughout the course, the broad-ranging applications for mass spectrometry are underscored, from forensics to geological/archaeological dating to biomolecule sequencing to studying atmospheric chemistry.