Office: 679 Natural Sciences Complex
Phone: (716) 645-4254
Fax: (716) 645-6963
Lab website: http://lin.chem.buffalo.edu
B.S., University of Science and Technology of China (1994)
M.S., University of Pittsburgh (1997)
Ph.D., Yale University (2000)
Damon Runyon Cancer Research Foundation Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA (2000-2003)
Awards and Honors:
Japan Society for the Promotion of Science (JSPS) Fellowship (2013)
National Academies Keck Future Initiatives in Synthetic Biology Grant Award (2010)
Our research program aims to develop and apply new chemical tools and principles to solve biological problems that are difficult to solve, if not impossible, by standard biological techniques. A central theme of our research is to harness the power of organic reactions to study protein dynamics, function, and assembly in living systems. We are currently working in the following three areas:
- Develop bioorthogonal reactions as a tool to study protein function in various cellular systems;
- Develop new enabling technologies for translating peptides into cancer therapeutics;
- Design nano-sized bioreactors for sustainable production of pharmaceuticals.
Please check our group page for details.
Selected Recent Publications:
- Reyna K. V. Lim, Nan Li, Carlo P. Ramil, and Qing Lin* “Fast and Sequence-Specific Palladium-Mediated Cross-Coupling Reaction Identified from Phage Display” ACS Chem. Biol. 2014, DOI: 10.1021/cb500443x. Highlighted in C&EN Science & Technology Concentrates, July 28, 2014.
- Carlo P. Ramil and Qing Lin* “Photoclick chemistry: A fluorogenic light-triggered in vivo ligation reaction” Curr. Opin. Chem. Biol. 2014, 21, 89-95.
- Zhipeng Yu and Qing Lin* “Design of spiro[2,3]hex-1-ene, a genetically encodable double-strained alkene for superfast photoclick chemistry” J. Am. Chem. Soc. 2014, 136, 4153-4156.
- Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Surya V. S. R. K. Pulavarti, Thomas Szyperski, Hong-Gang Wang*, and Qing Lin* ”Targeted Delivery of Ubiquitin-Conjugated BH3 Peptide-Based Mcl-1 Inhibitors into Cancer Cells” Bioconjugate Chem. 2014, 25, 424-432.
- Zhipeng Yu, Tymish Y. Ohulchanskyy, Peng An, Paras Prasad, and Qing Lin* “Fluorogenic, Two-Photon Triggered Photoclick Chemistry in Live Mammalian Cells” J. Am. Chem. Soc. 2013, 135, 16766-16769.
- Peng An, Zhipeng Yu, and Qing Lin* “Design and Synthesis of Laser-Activatable Tetrazoles for a Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction” Org. Lett. 2013, 15, 5496-5499.
- Carlo P. Ramil and Qing Lin* “Bioorthogonal Chemistry: Strategies and Recent Development” Chem. Comm. 2013, 49, 11007-11022. (Feature Article)
- Peng An, Zhipeng Yu, and Qing Lin* “Design of Oligothiophene-Based Tetrazoles for Laser-Inducible Photoclick Chemistry in Living Cells” Chem. Comm. 2013, 49, 9920-9922.
- Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang*, and Qing Lin* “Genetically Encoded Cyclopropene Directs Rapid, Photoclick Chemistry-Mediated Protein Labeling in Mammalian Cells” Angew. Chem. Int. Ed. 2012, 51, 10600-10604.
- Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Eric J. Drake, Andrew M. Gulick, Hong-Gang Wang, and Qing Lin* “Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors” J. Am. Chem. Soc. 2012, 134, 14734-14737. Recommended by Faculty of 1000 Pharmacology & Drug Discovery, September 27, 2012.