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Thomas Szyperski

Szyperski, ThomasUB Distinguished Professor
Director, UB High-Field NMR Facility
Adjunct Senior Researcher at the Hauptman-Woodward Medical Research Institute
Office: 816 Natural Sciences Complex
Phone: (716) 645-4309
Fax: (716) 645-6963

GFT Projection NMR webpage:

NMR 2.0 webpage:


Prediploma Biochemistry, U Tübingen (D) 1984
Prediploma Chemistry, TU Munich (D) 1985
Diploma Chemistry, TU Munich (D) 1988
Dr. sc. nat ETH, ETH Zürich (CH) 1992
Habilitation, ETH Zürich (CH) 1998
Visiting scientist, U Auckland (NZ) 1988
Fellow of the Studienstiftung des Deutschen Volkes (1982-1988)
Fellow im Verband der Chemischen Industrie (1989-1991)


Medaille der ETH 1992
Research Innovation Award 1999, Research Corporation
Buck-Whitney Medal 2003 of the ACS
Scientific American 50 Award 2003 for “Chemistry and Materials”
Laukien Prize 2006
2007 SUNY Chancellor’s Award for Excellence in Scholarship and Creative Activities


Structure determination of biological macromolecules using nuclear magnetic resonance (NMR) spectroscopy, Development of Bio-NMR techniques, Structural genomics, Metabonomics.


Research Summary:

Our research focuses on:

  1. Development of Bio-NMR methodology.
  2. Structure determinations of biological macromolecules using nuclear magnetic resonance (NMR) spectroscopy.
  3. Development of NMR-based structural biology in supercooled water.
  4. Investigation of cellular metabolism in support of biotechnology research.
  5. Metabonomics

NMR Instrumentation:

Varian 600 and 750 MHz spectrometers (cryogenic probes)
Access to: 500 (nanoprobe), 500 (1H/ 19F/ 13C/ 15N/ 2H-probe), 400, 300 MHz spectrometers

Selected Recent Publications:

  1. Sathyamoorthy, B., Singarapu, K.K., Garcia, A.E., Szyperski, T. (2013) Protein Conformational Space Populated in Solution Probed with Aromatic Residual Dipolar (13)C-(1)H Couplings. ChemBioChem 14:684-688. PMID:23494854
  2. Pulavarti, S.V., He, Y., Feldmann, E.A., Eletsky, A., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Kennedy, M.A., Szyperski, T. (2013) Solution NMR Structures Provide First Structural Coverage of the Large Protein Domain Family PF08369 and Complementary Structural Coverage of Dark Protochlorophyllide Oxidoreductase Complexes. J. Struct. Funct. Genomics 14: 119-126. PMID: 23963952
  3. Stark, J.L., Copeland, J.C., Eletsky, A., Somerville, G.A., Szyperski, T., Powers, R. (2014) Identification of Low-molecular-weight Compounds Inhibiting Growth of Corynebacteria: Potential Lead Compounds for Anitibiotics. ChemMedChem 9:282-285. PMID:24403054
  4. Sathyamoorthy, B., Parish, D.M., Montelione, G.T., Xiao, R., Szyperski, T. (2014) Spatially Selective Heteronuclear Multiple-quantum (HMQC) Spectroscopy for Bio-molecular Studies. ChemPhysChem 15:1872-1879. PMID:24789578.
  5. Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T. (2014) High-quality NMR Structure of Human Anti-apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
    PLoS One 9:e96521. PMID:24789074
  6. Pulavarti, S.V., Eletsky, A., Huang, Y.J., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Szyperski, T. (2015) Polypeptide Backbone, Cβ and Methyl Group Resonance Assignments of the 24 kDa Plectin Repeat Domain 6 from Human Protein Plectin. J. Biomol. NMR Assign. 9:135-138. PMID: 24722902
  7. Wu, X., Liu, R., Sathyamoorthy, B., Yamato, K., Liang, G., Shen, L., Ma, S., Sukumaran, D.K., Szyperski, T., Fang, W., He, L., Chen, X., Gong, B. (2015) Discrete Stacking of Aromatic Oligoamide Macrocycles. J. Am. Chem. Soc. 137:5879-5882. PMID:25909625
  8. Eletsky, A., Pulavarti, S.V., Beaumont, V., Gollnick, P., *Szyperski, T. (2015) Solution NMR Experiment for Measurement of 15N-1H Residual Dipolar Couplings in Large Proteins and Supramolecular Complexes. J. Am. Chem. Soc. 137:11242-11245. PMID:26293598
  9. Turkoglu, O., Zeb, A., Graham, S., Szyperski, T., Szender, J. B., Odunsi, K., Szyperski, T., Bahado-Singh, R. (2016) Metabolomics of Biomarker discovery in Ovarian Cancer: a Systematic Review of the Current Literature. Metabolomics 12: 60.
  10. Jacobs, T. M., Williams, B., Williams, T., Xu, X., Eletsky, A., Federizon, J. F., Szyperski, T., Kuhlman, B. (2016) Design of Structurally Distinct Proteins Using Strategies Inspired by Evolution. Science 352: 687-690. PMID: 27151863

Complete List of Publications